The homologous functional protein vIL-6 interacts with the cellular transmembrane protein gp130 to increase vascular permeability by inducing vascular endothelial growth factor (VEGF) (Morris et al. 2008; Sakakibara and Tosato 2011); promote cell proliferation (Han et al. 2024); induce angiogenesis and tumorigenesis by epigenetic regulation (Han et al. 2024); deregulate the NF-κB signaling pathway, a transcription factor involved in several pathophysiological processes of cancer (Charostad et al. 2020). This evidence concerns the gene VEGFA and cancer.