Neuroinflammation occurs simultaneously and is secondary to hypothalamic-pituitary-adrenal mediators (corticotropin-releasing hormone, adrenocorticotropic hormone, cortisol, and vasopressin) and inflammatory cytokines that cause inflammation and neuronal injury.28,29 These mechanisms can affect any patient; however, those with preexisting neurodegeneration, particularly older patients, and those with cognitive impairment and multimorbidity, including patients with cancer, are more severely affected. Here, CRH is linked to cancer.