Neuroinflammation occurs simultaneously and is secondary to hypothalamic-pituitary-adrenal mediators (corticotropin-releasing hormone, adrenocorticotropic hormone, cortisol, and vasopressin) and inflammatory cytokines that cause inflammation and neuronal injury.28,29 These mechanisms can affect any patient; however, those with preexisting neurodegeneration, particularly older patients, and those with cognitive impairment and multimorbidity, including patients with cancer, are more severely affected. This evidence concerns the gene CRH and Cognitive impairment.