Consistently, the knockdown of ZEB1-AS1 reduced HDAC2 and decreased the expression of hypertrophic markers, including B-type natriuretic peptide, atrial natriuretic peptide, and β-myosin heavy chain, thereby restraining the progression of CH.<h4>Conclusions</h4>ZEB1-AS1 is upregulated in myocardial tissues and ISO-stimulated AC16 cells. The gene discussed is NPPA; the disease is cyclic hematopoiesis.