In adult AML patients, women are more likely than men to have a normal karyotype and FLT3-ITD, DNMT3A, NPM1, and WT1 mutations, whereas complex karyotypes and ASXL1, SRSF2, U2AF1, RUNX1, or KIT mutations are less common [57]. The gene discussed is NPM1; the disease is acute myeloid leukemia.