TP53 and B-cell chronic lymphocytic leukemia: High genetic risk and laboratory markers, including unmutated immunoglobulin heavy chain variable (IGHV) genes, mutated or deleted tumor protein 53 (TP53) genes, 11q deletions, elevated beta-2 microglobulin concentrations, ZAP-70 positivity, and CD38 positivity, are less common in women with CLL than in men [24].