CRB1 (Crumbs Cell Polarity Complex Component 1) mutations, associated with both RP and Leber congenital amaurosis, and ABCA4 (ATP Binding Cassette Subfamily A Member 4) mutations, typically associated with Stargardt disease but also capable of causing RP phenotypes, were also identified. The gene discussed is CRB1; the disease is Stargardt disease.