For instance, PGK1 promotes glycolysis-driven aggressiveness in gastric and colorectal cancers; P4HA1 regulates collagen remodeling and hypoxia adaptation in breast and lung cancers; and SLC7A11/xCT contributes to ferroptosis resistance in pancreatic, glioma, and prostate cancer models. The gene discussed is PGK1; the disease is Familial prostate cancer.