For instance, PGK1 promotes glycolysis-driven aggressiveness in gastric and colorectal cancers; P4HA1 regulates collagen remodeling and hypoxia adaptation in breast and lung cancers; and SLC7A11/xCT contributes to ferroptosis resistance in pancreatic, glioma, and prostate cancer models. Here, SLC7A11 is linked to Familial prostate cancer.