For instance, PGK1 promotes glycolysis-driven aggressiveness in gastric and colorectal cancers; P4HA1 regulates collagen remodeling and hypoxia adaptation in breast and lung cancers; and SLC7A11/xCT contributes to ferroptosis resistance in pancreatic, glioma, and prostate cancer models. This evidence concerns the gene P4HA1 and Familial prostate cancer.