FGFR1 and Hartsfield-Bixler-Demyer syndrome: This is a rare skeletal development disorder, namely FGFR1-related Hartsfield syndrome (HRTFDS, MIM#615465), which is characterized by a wide range of limb defects severity, comprising variable degrees of median clefts of the hands and/or feet (hypoplasia/absence of central rays), aplasia and syndactyly.