The associated phenotypes are the Ectrodactyly, ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3; MIM#) [27], Acro-dermo-ungual-lacrimal-tooth (ADULT) syndrome (MIM#103285) [28], Limb-mammary syndrome (LMS, MIM#603543) [29] and Split-hand/foot malformation type 4 (SHFM4, MIM#605289) [30] and orofacial cleft 8 (OFC8, MIM#618149) [31]. This evidence concerns the gene TP63 and split hand-foot malformation.