Pathogenetic heterozygous variants in the Fibroblast Growth Factor Receptor 1 gene (FGFR1, MIM*136350) have been associated with a wide group of genetic conditions, including hypogonadotropic hypogonadism 2 with or without anosmia (Kalmann syndrome, KAL2; MIM#147950) [1], trigonocephaly 1 (TRIGNO1, MIM#190440) [2], Osteoglophonic dysplasia (OGD; MIM#166250) [3], Pfeiffer (MIM#101600) [4] and Jackson-Weiss [5] (JWS; MIM#123150) syndromes. This evidence concerns the gene FGFR1 and osteoglophonic dysplasia.