CBD attenuated hepatic steatosis and injury (↓ TG, ↓ hepatic cholesterol, ↓ serum ALT/AST), reduced oxidative stress (improved GSH/GSSG ratio, ↓ MDA), decreased macrophage infiltration (↓ CD68), downregulated proinflammatory cytokines (↓ IL-1β, ↓ MCP-1, ↓ TNF-α), and inhibited the NF-κB/NLRP3/pyroptosis axis. Here, CCL2 is linked to fatty liver disease.