Additional tests for the investigation of post-streptococcal complications and rheumatic diseases include antistreptolysin O (ASTO), antideoxyribonuclease B (anti-DNAse B), antinuclear antibodies (ANA), anti-double-strand deoxyribonucleic acid (anti-dsDNA), cellular antineutrophil cytoplasmic antibodies (c-ANCA), perinuclear antineutrophil cytoplasmic antibodies (p-ANCA), immunoglobulins, complement, and angiography [7,16]. The gene discussed is PRTN3; the disease is rheumatic disorder.