Thymoma is the classic association for myasthenia gravis (AChR antibodies) but is also strongly linked to central nervous system (CNS) syndromes such as Morvan syndrome and limbic encephalitis (LE), mediated by anti-CASPR2, anti-LGI1, and anti-CRMP5 antibodies [19,22,23]. The gene discussed is LGI1; the disease is myasthenia gravis.