Neuroendocrine lineage-associated antigens such as DLL3 are highly expressed in SCLC and closely linked to ASCL1- and NEUROD1-driven transcriptional programs, which define the predominant neuroendocrine subtypes (SCLC-A and SCLC-N) [6,80,81]. This evidence concerns the gene ASCL1 and small cell lung carcinoma.