Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that plays a key role antioxidant response and is involved in the onset and progression of several cancerous and non-cancerous diseases [118,119,120] and is emerging as a pivotal determinant: Nrf2-deficient murine embryonic fibroblasts and cisplatin-resistant SK-OV ovarian cancer cells display a clear correlation between Nrf2 levels and drug resistance. This evidence concerns the gene NFE2L2 and ovarian cancer.