This is revealed by histological scores on a study of 125 patients with cSCC (Klintrup–Mäkinen (KM) Score 1.8, standard deviation (SD) 0.85) compared to adjacent normal skin (KM score 0.82, (SD) 0.46), Actinic Keratosis (AK) (KM score 1.28, SD 0.52) and SCC in situ (KM score 1.66, SD 0.63) [25], building on Stravodimou et al.’s previous results where CD8+ T-cells showed the same pattern but it was noted that aggressive types of SCC (acantholytic/adenoid, adenosquamous, spindle cell and desmoplastic subtypes) had fewer CD3+ cells [21]. This evidence concerns the gene CD8A and actinic keratosis.