A reduced number of inflammatory infiltrate was also observed in EB-associated SCC, with significantly lower numbers of CD4+ T-cells (mean: 649 cells/mm2) and CD8+ T-cells (mean 794 cells/mm2) compared with SCCs from immunocompetent patients (mean CD4+: 1211 cells/mm2, mean CD8+ T-cells: 1228/mm2) [58]. This evidence concerns the gene CD4 and epidermolysis bullosa.