A statistically significant difference (p < 0.05, chi-square = 94.1) was observed with Angiopoietin 2 (50% (3/6) showed no staining, 33.3% (2/6) showed grade 1 staining, and 16.7% (1/6) showed grade 2 staining in control group, and 10% (1/10) showed grade 1 staining, 40% (4/10) showed grade 2 staining, and 50% (5/10) showed grade 3 staining in rosacea group). This evidence concerns the gene ANGPT2 and rosacea.