For example, the hypermethylation of specific CpG sites of the genes MICAL3 (microtubule associated monooxygenase), MAD1L1 (Mitotic Spindle Assembly checkpoint protein), and METTL22 (Methyltransferase-like protein) at defined levels have been found to be associated with UC-CRC. Here, METTL22 is linked to colorectal carcinoma.