EZH2 and colorectal carcinoma: A study by Carvalho et al. retrospectively examined tissue from 207 CRC patients and evaluated the expression of histone-modifying enzymes EZH2 and SETDB1 (histone methyltransferases), and LSD-1 (histone demethylase), which are associated with trimethylation of lysine 27 and lysine 9 on histone H3 (H3K27me3 and H3K9me3, respectively).