Fisetin (20 μM, 48 h) markedly reduced 5′ CpG promoter methylations and reactivated several TSGs, including TP53, PTEN (PINK1), RASSF1, RUNX1, APC2, DAPK1, FOXO3, PERP, RARβ, SOCS1, SOX1, CDH13, TIMP2, TIMP3, WIF1, and VHL, many of which are silenced in cervical cancer (Figure 5a). The gene discussed is PTEN; the disease is cervical cancer.