It is encouraging to know that a variety of bioactive phytochemicals can modulate several epigenetic enzymes such as HDAC, HAT, DNMT, and HMT [13] that may consequently alter the expression of important tumor suppressor, oncogene, and tumor promoter genes, etc. Polyphenols like Quercetin, chrysin, EGCG, myricetin, etc., are confirmed to hinder activities of HDAC and DNMT, with the subsequent reactivation of TSG [5]. The gene discussed is HDAC9; the disease is neoplasm.