Aberrant DNA hypermethylation and chromatin modifications contribute to the silencing of tumor suppressor genes (TSGs) such as BRCA1, p53, p21, p27, RARβ, hMLH1, DAPK, CDH1, p16, APC, MSH2, PTEN, and MLH1 in various cancers [35]. The gene discussed is RARB; the disease is cancer.