BCL2 and lymphoma: Notably, cases displaying a gray zone lymphoma phenotype but not fulfilling the current diagnostic definition of mediastinal involvement (historically categorized as GZL) exhibit a distinct mutational landscape, with higher frequencies of TP53 (39%), BCL2 (28%), and BIRC6 (22%) mutations, as well as more frequent BCL2 and BCL6 rearrangements [9,25].