Podocyte injury, characterized by foot process effacement (FPE), cytoskeletal disorganization, and loss of slit diaphragm proteins (nephrin and podocin), is the final common pathway to proteinuria in diverse glomerulopathies, including membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), and DKD (Kopp et al. Here, NPHS1 is linked to focal segmental glomerulosclerosis.