Across the majority of tumor types, TP53/RB1 co‐altered tumors were significantly enriched for gene sets related to neuronal development and cell cycle progression, whereas those related to extracellular matrix (NABA matrisome associated) and to immune response and inflammation were consistently de‐enriched gene sets (Figure 4A–F and Figure S3). The gene discussed is RB1; the disease is neoplasm.