In TP53/RB1 co‐mutant colon adenocarcinoma and rectum adenocarcinoma (COADREAD), highly recurrent genomic alterations were identified in a core set of genes, including APC (77%), FBXW7 (43%), KRAS (43%), PIK3CA (42%), and POLE (41%) (Figure 3F). This evidence concerns the gene POLE and rectum adenocarcinoma.