Additionally, 14 genes such as GRIN2D, HTR7, and CCKAR were found to be upregulated in the calcium signaling pathway, while 43 genes, including ATP2A1, ADCY8, and MCOLN3, were significantly downregulated, suggesting that calcium signaling plays a critical role in the pathology of keloids (Figure 2D). The gene discussed is ADCY8; the disease is keloid.