NLRP3 and amyotrophic lateral sclerosis: Among the PRRs triggering microglial reactivity, the intracellular NOD-like receptor protein 3 (NLRP3) has been shown to play essential roles in various neuropathological conditions such as Parkinson ́s disease (PD), Alzheimer ́s disease (AD), and Amyotrophic lateral sclerosis (ALS) (4–7).