One study maps epithelial-mesenchymal transition (EMT)-related DEGs in PCa, validates findings in TCGA, and highlights ECM-linked biomarkers for diagnosis and therapeutic targeting, including integrin subunit beta like 1 (ITGBL1), desmocollin 3 (DSC3), collagen type IV alpha 6 chain (COL4A6), angiopoietin 1 (ANGPT1), armadillo repeat containing, X-linked 1 (ARMCX1), microtubule associated monooxygenase, calponin and LIM domain containing 2 (MICAL2), EPH receptor A5 (EPHA5) (43). The gene discussed is COL4A6; the disease is posterior cortical atrophy.