TRPM6 demonstrated a significant positive correlation with TMB in uterine serous carcinoma (USC) and ACC (P < 0.05), whereas a robust negative association was observed in BLCA, COAD, and kidney renal papillary cell carcinoma (KIRP) (P < 0.05, Figure 7A). This evidence concerns the gene TRPM6 and endometrial serous adenocarcinoma.