LTBP3 and neoplasm: Literature indicates that Latent TGF-β Binding Protein 3 (LTBP-3) plays a crucial role in cancer metastasis by regulating angiogenesis and influencing the early dissemination and invasion of cancer cells from the primary tumor, although it is not essential for later stages of metastasis, such as vascular arrest, extravasation, and colonization (17).