Hypermethylation of PELI1 occurred in colon adenocarcinoma (COAD), HNSC, KIRC, LUAD, READ, SKCM, thyroid carcinoma (THCA) and UCEC (Supplementary Figure S1A), while hypomethylation was observed in kidney renal papillary cell carcinoma (KIRP), LIHC, prostate adenocarcinoma (PRAD) (Supplementary Figure S1A). The gene discussed is PELI1; the disease is thyroid gland carcinoma.