IL22 and parasitic infectious disease: To elucidate the role of IL-22 in liver injury caused by AE, we generated an E.m-infected murine model and manipulated IL-22 bioactivity by administering recombinant IL-22 protein (rIL-22 group) or its high-affinity inhibitor rIL-22BP (rIL-22BP group), thereby interrogating the impact of IL-22-directed intervention on parasite infection (Figure 2A).