Finally, although Ang-(1–7) (80) and alamandine were not measured, our preliminary data point to a trend of reduced expression of MasR and MrgD receptors (50), which implies that obesity and SARS-CoV-2 infection may contribute to decreased protective RAAS signaling (4, 40, 81). The gene discussed is ANG; the disease is obesity due to melanocortin 4 receptor deficiency.