AKT1 and neoplasm: This change is also tactically exploited by tumor microenvironments: in gastric cancer (101), this modification using lactate to induce H3K18 lactylation, induces VCAM1 expression, subsequently activating AKT-mTOR-CXCL1 signaling to recruit and polarize M2 macrophages, whereas in ovarian cancer (102), this modification is used to activate M2 polarization by CCL18 upregulation,facilitating immune evasion and metastasis.