ICOSLG and neoplasm: Whereas the proportions of ICP-L-expressing iNKT cells (ICOSL, PDL2, and OX40L) (Figure 3D, Supplementary Figure S2C) decreased in tumors compared with non-tumoral tissues, we observed that LAG3 was the only ICP whose expression was highly heightened on tumor-infiltrating iNKT cells compared with non-tumoral tissues (Figure 3E).