We observed that the circulating iNKT cells from patients with melanoma exhibited higher levels of NKG2A, NKG2D, and NKp44 compared with those from HDs, and tumor-infiltrating iNKT cells expressed more NKG2A, NKG2C, and NKp44 compared with the blood of patients and HDs (Figure 3C, Supplementary Figure S2B). This evidence concerns the gene KLRK1 and melanoma.