To gain insights into the impact of melanoma on iNKT cells, we assessed their differentiation stage, their activation status, their expression of NCR/KLR, and the ICP molecules (Figure 3, Supplementary Figures S1B–F; S2), as these molecules determine the fate of iNKT cells and orientate their potentialities to interact with target cells and subsequently modulate other immune cells. Here, KLRK1 is linked to melanoma.