The expression of CD69, PD1, or LAG3 by iNKT cells from the blood of HDs and patients was associated with a higher level of global metabolism compared with non-expressing cells, whereas the metabolic activity did not differ between the CD69-, PD1-, or LAG3-expressing and non-expressing tumor-infiltrating iNKT cells (Figure 6A). This evidence concerns the gene PDCD1 and neoplasm.