The dampened glucose dependency observed in tumor-infiltrating iNKT cells is in line with observations in tumor-bearing mice, where circulating and tumor-infiltrating iNKT cells exhibited an unbalanced metabolism characterized by a suppressed glucose metabolism (decreased expression of the transporters Glut1 and Glut3 and of the glycolysis-related enzymes) (23). The gene discussed is SLC2A1; the disease is neoplasm.