HIF1A and acute respiratory distress syndrome: Notably, HIF-1 activation exhibits cell type-specific effects during S-ALI progression: in early stages, it regulates inflammation, vascular leakage, and remodeling in immune and endothelial cells; during progressive stages of S-ALI, HIF-1 activation in alveolar type II epithelial cells becomes essential for epithelial cell proliferation and tissue regeneration.