WNT2 and neoplasm: In NPC, ALKBH5 cooperated with YTHDF1 to stabilize WNT2 mRNA and elevate WNT2 protein levels, which not only promoted M2 polarization of TAMs but also enhanced tumor cell proliferation and metastasis via autocrine activation of the FZD2/β-catenin axis, establishing a vicious cycle (54).