In intrahepatic cholangiocarcinoma, ALKBH5 directly binds and demethylates PD-L1 mRNA, reducing m6A modification in its 3′UTR, which prevents YTHDF2-mediated degradation, stabilizes PD-L1 expression, and suppresses T cell expansion and cytotoxicity (58). Here, CD274 is linked to intrahepatic cholangiocarcinoma.