Given the involvement of CLU and LCN2 in the progression of pulmonary fibrosis and regulation of cellular senescence, it is hypothesized that inulin and meclizine may exert an anti-pulmonary fibrosis effect in the lungs by targeting these genes and modulating cellular senescence, offering a potential new therapeutic approach for IPF. Here, LCN2 is linked to idiopathic pulmonary fibrosis.