Our study systematically identified 10 hub genes (IGFBP7, CLU, HMGCR, SOX4, LCN2, TLR4, MDK, MMP7, GDF15, and SOX2) that act as dual-functional regulators of fibrotic remodeling and cellular senescence in IPF. This evidence concerns the gene TLR4 and idiopathic pulmonary fibrosis.