NFKB1 and pulmonary fibrosis: These evidences suggest that pulmonary fibrosis may involve similar neuroglial related mechanisms, such as sympathetic nerve activation regulating the activity of pulmonary fibroblasts through adrenergic receptors (53, 54), neuroglia-immune cell interaction mediated by the NF-κB pathway mediating chronic inflammatory responses (55), and tissue microenvironment remodeling induced by neuroglial- derived factors.