While METTL1 exhibits clear oncogenic activity in certain malignancies, such as ICC and HCC (7, 43), where it promotes tumor proliferation, metastasis, and immune evasion, studies have also reported potential tumor-suppressive roles of METTL1 in other cancers, including breast cancer (41). The gene discussed is METTL1; the disease is intrahepatic cholangiocarcinoma.