PDGFRA and Marfan syndrome: In this regard, vascular endothelial growth factor (VEGF) plays a key role in angiogenesis, and its expression in MFS has been well-documented; mRNA in situ hybridization revealed high expression of VEGF and thrombospondin-1 by MFS neoplastic cells (13), and immunohistochemistry (IHC) highlighted a diffuse and strong expression of VEGF-A and PDGFRα in MFS (14).