EGR1 plays an important role in cancer by promoting tumorigenesis through enhanced cyclin D1 expression in prostate cancer and by interacting with vascular endothelial growth factor A (VEGFA) to stimulate angiogenesis in lung cancer (Xiao et al., 2005; Shimoyamada et al., 2010). The gene discussed is VEGFA; the disease is Familial prostate cancer.