WWOX and Alzheimer disease: Other loci that emerged from both GWASs with high relevance to CNS include WW domain containing oxidoreductase (WWOX), which has been associated with various complex and rare monogenic brain pathologies, including ASD, intellectual disability (ID), and attention-deficit/hyperactivity disorder (ADHD) (Sanders et al., 2011; Harich et al., 2020), along with AD (Kunkle et al., 2019), multiple sclerosis (MS) (Beecham et al., 2013), spinocerebellar ataxia type 12 (SCAR12; OMIM #614322), and WWOX-related epileptic encephalopathy syndrome (OMIM #616211) (Aldaz and Hussain, 2020).