ADAM metallopeptidase with thrombospondin type 1 motif 17 (ADAMTS17) encodes a secreted metalloprotease that is highly expressed in the brain and retina (Morales et al., 2009) and is implicated in ECM remodeling and organization, as well as in a hereditary eye disease (Hubmacher et al., 2017). The gene discussed is ADAMTS17; the disease is eye disorder.