VEGFA and POEMS syndrome: Based on research, mechanisms such as monoclonal plasma cell proliferation, 14q32 chromosomal translocations and 13q14 chromosomal deletions, Epstein-Barr virus and human herpesvirus 8 infections, along with excessive production of proinflammatory cytokines and VEGF, are thought to play significant roles in the onset and progression of POEMS syndrome (12).