Univariable regression showed that age, male sex, Hispanic ethnicity, BMI, history of cardiovascular complications, pre-existing respiratory disease, DM, CKD, cancer, liver disease, dementia, higher level of baseline respiratory support, decreases in albumin, decreases in platelets, and increases in CRP, d-dimer, hemoglobin, INR, BUN, and LDH at admission were associated with increased risk of severe disease in our cohort (Supplementary Table S2). The gene discussed is ALB; the disease is liver disorder.