PLAU and hepatocellular carcinoma: For instance, in major urinary protein (MUP)-urokinase-type plasminogen activator (uPA) mice which were prone to ER stress, hepatocyte-derived ATF4 suppressed the progression of diethylnitrosamine- and high fat diet-induced hepatocellular carcinoma through upregulating the expression of solute carrier family 7a member 11 (SLC7A11), which was necessary for glutathione synthesis and protective against ferroptosis (He et al., 2023).