ATF4 and familial dilated cardiomyopathy: By applying an in vitro DCM model recaptured by induced pluripotent stem cell-cardiomyocytes (iPSC-CMs) carrying the TNNT2 R183W mutation, this study showed that ATF4 was indispensable in mediating the beneficial effects of two small molecule kinase inhibitors, Gö 6976 and SB 203580, on rescuing the contractile function of cardiomyocytes (Perea-Gil et al., 2022).