PHGDH knockdown accelerated while PHGDH overexpression delayed the senescence of HUVECs, and vascular endothelium-specific overexpression of PHGDH prevented dilated cardiomyopathy, improved cardiac function, promoted endothelial function and slowed down cellular senescence in aged mice (Wu et al., 2023). The gene discussed is PHGDH; the disease is dilated cardiomyopathy.