In terms of anti-inflammatory cytokines, increased serum interleukin-10 (IL-10) levels are associated with a reduced risk of future cardiac events because it plays a role in inhibiting the occurrence of atherosclerosis and systemic inflammation, including inhibiting nuclear factor-κB activation, metalloproteinases, tissue factor expression, and apoptosis (72, 78). The gene discussed is F3; the disease is atherosclerosis.