By participant health status: one study on healthy older adults (56) showed the most significant CRP reduction of 1.8 mg/L (MD = −1.8 mg/L, 95% CI: −2.76 to −0.84); two studies on patients with diabetes (51, 64) reported a reduction of 0.18 mg/L (MD = −0.18 mg/L, 95% CI: −0.25 to −0.10); five studies on obese adults (49, 53, 59, 62, 63) showed a modest reduction of 0.06 mg/L (MD = −0.06 mg/L, 95% CI: −0.09 to −0.03); and four studies on elderly patients with MetS (47, 50, 52, 57) had a minimal reduction of 0.01 mg/L (MD = −0.01 mg/L, 95% CI: −0.01 to 0.03). The gene discussed is CRP; the disease is diabetes mellitus.