Leveraging the established role of COL1A2 in orchestrating extracellular matrix (ECM) remodeling as a pivotal driver of bladder cancer progression, we first characterized its transcriptional profile across a panel of bladder cancer cell lines modeling distinct pathological stages (normal urothelium: SV-HUC-1; low-invasive/NMIBC-like: SW1710; highly invasive/MIBC-like: T24). The gene discussed is COL1A2; the disease is urinary bladder carcinoma.