The DNMT3A mutation is closely associated with treatment resistance and clonal evolution (25).The CSF3R mutation can activate the JAK-STAT pathway (26), and it is hypothesized that this may enhance the sensitivity of leukemia cells to factors such as G-CSF in the central nervous system microenvironment, thereby promoting their migration to and survival within the CNS (27), ZBTB7A, as a transcriptional repressor and potential tumor suppressor gene, its mutation may promote cell proliferation and impair differentiation ability by releasing the inhibition of multiple target genes. The gene discussed is DNMT3A; the disease is leukemia.