The DNMT3A mutation is closely associated with treatment resistance and clonal evolution (25).The CSF3R mutation can activate the JAK-STAT pathway (26), and it is hypothesized that this may enhance the sensitivity of leukemia cells to factors such as G-CSF in the central nervous system microenvironment, thereby promoting their migration to and survival within the CNS (27), ZBTB7A, as a transcriptional repressor and potential tumor suppressor gene, its mutation may promote cell proliferation and impair differentiation ability by releasing the inhibition of multiple target genes. This evidence concerns the gene CSF3 and leukemia.