Finally, a genome-wide correlation scan in GBM showed that the genes positively associated with OPCML are enriched for extracellular matrix (ECM) organization and synaptic signaling, whereas the negatively associated genes cluster in cell cycle and DNA replication pathways (Figure 3F), suggesting that a reduced OPCML expression accompanies proliferative programs in GBM. The gene discussed is OPCML; the disease is glioblastoma.