This pattern is in line with IgLON biology—these molecules support neural adhesion, synaptogenesis, and circuit maturation—and it matches our correlation signatures in GBM: genes positively tracking with OPCML were enriched for synaptic and ECM organization, whereas negatively tracking genes clustered in cell cycle and replication pathways (6, 14, 15). Here, OPCML is linked to glioblastoma.