Therefore, the aim of the present study was to analyze the concentrations of all 11 members of the IL-1 family (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-37, IL-1Ra, IL-36Ra, IL-38) in the serum and peritoneal fluid of patients with ovarian cancer and to determine the relationship between the parameters studied and the degree of histological differentiation of ovarian cancer. This evidence concerns the gene IL18 and ovarian cancer.