In vitro studies conducted to date have shown that an imbalance in cytokines secreted by Th1/Th2 lymphocytes affects interactions between SKOV-3 ovarian cancer cells and immune system cells, manifested by changes in the secretion of pro-inflammatory cytokines such as IL-1β, IL-6, and IL-12 (42). This evidence concerns the gene IL1B and ovarian carcinoma.