Given that AF has been shown to alleviate cognitive disorders [17] and MAP2K1 regulates the HIF‐1α signaling pathway [18], while hyperuricemia activates the ERK pathway influencing HIF‐1α [19], we investigated whether AF improves HUA‐CI by modulating the HIF‐1 signaling pathway. The gene discussed is MAP2K1; the disease is atrial fibrillation.