In summary, this study identifies circIMP3, a highly upregulated circRNA in PC that encodes the oncogenic peptide circIMP3_288aa, drives FBXW7 exon skipping to stabilize c-Myc, promotes tumor progression both intracellularly and via exosome-mediated paracrine signaling, and serves as a promising prognostic biomarker detectable in blood (Figure 7). Here, MYC is linked to neoplasm.