Previous studies have shown that SOD deficiency accelerates amyloid β oligomerization or promotes tau protein phosphorylation in Alzheimer’s disease (AD) model mice (Murakami et al., 2011; Massaad et al., 2009; McLimans et al., 2019), suggesting a critical pathway by which SOD deficiency may influence VCI. This evidence concerns the gene SOD1 and early-onset autosomal dominant Alzheimer disease.