IL6 and cancer: Figure 2 shows the ROC curve for serum IL-6, demonstrating its discriminatory ability. The area under the curve (AUC) was 0.814 (95%CI: 0.704–0.925), indicating good diagnostic performance. The optimal serum IL-6 cut-off value for distinguishing between CC patients and their cancer-free counterparts was 365.1 ng/mL, corresponding to a sensitivity of 66.7% and a specificity of 86.7%.