Interestingly, in the present study, L1CAM-positive tumours showed worse outcomes than p53wt/L1CAMneg, similar to the presence of p53 aberrant tumours and the combination of p53ab/L1CAMpos seems to have an increased risk of recurrence and death compared to the presence of only L1CAMpos or p53ab. This evidence concerns the gene TP53 and neoplasm.