Surprisingly, vaccination with SNAP-AD5 downregulated proinflammatory cytokines/chemokines of IL-2, IL-6, IL-12P70, IFNγ and MIP-2/CXCL2 in WT mice, and IFNγ in 3xTg-AD mice (Fig. 6D). Here, IL6 is linked to Alzheimer disease.